Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi.
نویسندگان
چکیده
The BBK32 protein binds to host extracellular ligand fibronectin and contributes to the pathogenesis of Borrelia burgdorferi. Here we showed that expression of the BBK32 gene is influenced by multiple environmental factors and that its regulation is governed by the response regulator Rrp2 and RpoN-RpoS (sigma(54)-sigma(S)) sigma cascade in B. burgdorferi.
منابع مشابه
Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity.
BBK32, a fibronectin-binding protein of Borrelia burgdorferi, is one of many surface lipoproteins that are differentially expressed by the Lyme disease spirochete at various stages of its life cycle. The level of BBK32 expression in B. burgdorferi is highest during infection of the mammalian host and lowest in flat ticks. This temporal expression profile, along with its fibronectin-binding acti...
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عنوان ژورنال:
- Journal of bacteriology
دوره 189 22 شماره
صفحات -
تاریخ انتشار 2007